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( e , f ) Levels of NADPH ( e ) and GSH ( f ) in WT and cpt1ept1 cells switched to fresh minimal medium for indicated times after a 30-min H 2 O 2 treatment

Discussion Chronic respiratory diseases such as COPD and lung cancer are leading causes of morbidity and mortality globally, with CS being a primary risk factor 3

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Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue